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Kdm6b antibody (C-Term)

This anti-Kdm6b antibody is a Rabbit Polyclonal antibody detecting Kdm6b in WB, ELISA, IF and ICC. Suitable for Human, Mouse and Rat.
Catalog No. ABIN6990705

Quick Overview for Kdm6b antibody (C-Term) (ABIN6990705)

Target

See all Kdm6b Antibodies
Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Reactivity

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Human, Mouse, Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This Kdm6b antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Binding Specificity

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    AA 1370-1420, C-Term

    Specificity

    This antibody is specific for JMJD3 and will not recognize other JMJD proteins.

    Purification

    JMJD3 Antibody is affinity chromatography purified via peptide column.

    Immunogen

    Anti-JMJD3 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human JMJD3. The immunogen is located within amino acids 1370-1420 of JMJD3.

    Isotype

    IgG
  • Application Notes

    WB: 0.25-4 μ,g/mL, ICC: 2.5 μ,g/mL, IF: 20 μ,g/mL.

    Antibody validated: Western Blot in human, mouse and rat samples, Immunocytochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    JMJD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    JMJD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

    Alternative Name

    JMJD3

    Background

    JMJD3 Antibody: The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.

    Molecular Weight

    Predicted: 180

    Observed: 180 kD kDa

    Gene ID

    23135

    UniProt

    O15054

    Pathways

    Warburg Effect
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