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NPAS3 antibody (AA 470-520)

NPAS3 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990741
  • Target See all NPAS3 Antibodies
    NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))
    Binding Specificity
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 470-520
    Reactivity
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 6
    Rabbit
    Clonality
    • 6
    Polyclonal
    Conjugate
    • 6
    This NPAS3 antibody is un-conjugated
    Application
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    NPAS3 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    NPAS3 antibody was raised against a 28 amino acid synthetic peptide from near the center of human NPAS3. The immunogen is located within amino acids 470 - 520 of NPAS3.
    Isotype
    IgG
    Top Product
    Discover our top product NPAS3 Primary Antibody
  • Application Notes
    NPAS3 antibody can be used for detection of NPAS3 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    NPAS3 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    NPAS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))
    Alternative Name
    NPAS3 (NPAS3 Products)
    Synonyms
    trh antibody, mop6 antibody, pasd6 antibody, MGC145768 antibody, MOP6 antibody, PASD6 antibody, bHLHe12 antibody, 4930423H22Rik antibody, neuronal PAS domain protein 3 antibody, npas3 antibody, NPAS3 antibody, Npas3 antibody
    Background
    NPAS3 Antibody: Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.
    Gene ID
    64067
    UniProt
    Q8IXF0
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