TACR3 antibody (AA 370-420)

Catalog No. ABIN6990763

This Rabbit Polyclonal antibody specifically detects TACR3 in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for TACR3 antibody (AA 370-420) (ABIN6990763)

Target: TACR3 (Tachykinin Receptor 3 (TACR3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TACR3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TACR3 Antibody

Binding Specificity: AA 370-420

Specificity: NK3R antibody does not recognize NK1R or NK2R.

Purification: NK3R Antibody is affinity chromatography purified via peptide column.

Immunogen: NK3R antibody was raised against a 18 amino acid synthetic peptide from near the center of human NK3R. The immunogen is located within amino acids 370 - 420 of NK3R.

Isotype: IgG

Application Details

Application Notes: NK3R antibody can be used for detection of NK3R by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NK3R Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NK3R antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TACR3

Target: TACR3 (Tachykinin Receptor 3 (TACR3))

Alternative Name: NK3R

Background: NK3R Antibody: The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.

Molecular Weight: Predicted: 51 kDa

Observed: 51 kDa

Gene ID: 6870

UniProt: P29371

Pathways: Feeding Behaviour