Influenza A Matrix Protein 2 antibody (Avian Influenza Virus) (N-Term)

Catalog No. ABIN6990796

Product Details

Target: Influenza A Matrix Protein 2 (M2)

Binding Specificity: N-Term

Reactivity: Avian Influenza Virus

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA

Purification: Avian Influenza A M2 Antibody is affinity chromatography purified via peptide column.

Immunogen: M2 antibody was raised against a 13 amino acid synthetic peptide from amino terminus of H5N1 M2. The immunogen is located within the first 50 amino acids of Avian Influenza A M2.

Isotype: IgG

Application Details

Application Notes: M2 antibody can be used for the detection of the M2 protein from the H5N1 strain of avian influenza A in ELISA. It will detect 10 ng of free peptide at 1 mg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Avian Influenza A M2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Avian Influenza A M2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details

Target: Influenza A Matrix Protein 2 (M2)

Alternative Name: Avian Influenza A M2 (M2 Products)

Synonyms: matrix protein 2 antibody

Target Type: Influenza Protein

Background: Avian Influenza A M2 Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, however, it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. The more recent virulent strain of H5N1 is now seen in Africa and Europe, as well as in Southeast Asia. There is some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. The influenza membrane ion channel (M2) is a small transmembrane protein that regulates the pH inside the virion during viral entry into the cell and protects the newly synthesized hemagglutinin during their transport through low pH cellular compartments. It has been suggested as a target of neutralizing antibodies.

UniProt: Q2L7I8