DLGAP3 antibody (C-Term)

Catalog No. ABIN6990832

Product Details anti-DLGAP3 Antibody

Target: DLGAP3 (Discs, Large (Drosophila) Homolog-Associated Protein 3 (DLGAP3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLGAP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: SAPAP3 Antibody is affinity chromatography purified via peptide column.

Immunogen: SAPAP3 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human SAPAP3. The immunogen is located within the last 50 amino acids of SAPAP3.

Isotype: IgG

Application Details

Application Notes: SAPAP3 antibody can be used for detection of SAPAP3 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SAPAP3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SAPAP3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DLGAP3

Target: DLGAP3 (Discs, Large (Drosophila) Homolog-Associated Protein 3 (DLGAP3))

Alternative Name: SAPAP3 (DLGAP3 Products)

Synonyms: DAP3 antibody, SAPAP3 antibody, BC058433 antibody, DAP-3 antibody, Prpl8 antibody, Sapap3 antibody, Dap3 antibody, DLG associated protein 3 antibody, discs, large (Drosophila) homolog-associated protein 3 antibody, DLGAP3 antibody, Dlgap3 antibody, dlgap3 antibody

Background: SAPAP3 Antibody: SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist.

Gene ID: 58512

UniProt: O95886