SLITRK1 antibody (AA 270-320)

Catalog No. ABIN6990850

Product Details anti-SLITRK1 Antibody

Target: SLITRK1 (SLIT and NTRK-Like Family, Member 1 (SLITRK1))

Binding Specificity: AA 270-320

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLITRK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

Purification: Slitrk1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Slitrk1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human Slitrk1. The immunogen is located within amino acids 270 - 320 of Slitrk1.

Isotype: IgG

Application Details

Application Notes: Slitrk1 antibody can be used for detection of Slitrk1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Slitrk1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Slitrk1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SLITRK1

Target: SLITRK1 (SLIT and NTRK-Like Family, Member 1 (SLITRK1))

Alternative Name: Slitrk1 (SLITRK1 Products)

Synonyms: DKFZp459G0529 antibody, LRRC12 antibody, TTM antibody, 3200001I04Rik antibody, SLIT and NTRK like family member 1 antibody, SLIT and NTRK-like family, member 1 antibody, SLITRK1 antibody, slitrk1 antibody, Slitrk1 antibody

Background: Slitrk1 Antibody: SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.

Gene ID: 114798

NCBI Accession: NP_443142

UniProt: Q96PX8