LGI4 antibody (AA 240-290)

Catalog No. ABIN6990873

Product Details anti-LGI4 Antibody

Target: LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))

Binding Specificity: AA 240-290

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGI4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Two isoforms of LGI4 are known to exist, this LGI4 antibody will recognize only the larger form. This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.

Purification: LGI4 Antibody is affinity chromatography purified via peptide column.

Immunogen: LGI4 antibody was raised against a 14 amino acid synthetic peptide from near the center of human LGI4. The immunogen is located within amino acids 240 - 290 of LGI4.

Isotype: IgG

Application Details

Application Notes: LGI4 antibody can be used for the detection of LGI4 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LGI4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LGI4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for LGI4

Target: LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))

Alternative Name: LGI4 (LGI4 Products)

Synonyms: Lgil3 antibody, clp antibody, LGIL3 antibody, leucine rich repeat LGI family member 4 antibody, leucine-rich repeat LGI family, member 4 antibody, LGI4 antibody, Lgi4 antibody

Background: LGI4 Antibody: The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.

Gene ID: 163175

UniProt: Q8N135