NIPSNAP (AA 130-180) antibody

Catalog No. ABIN6990879

The Rabbit Polyclonal anti-NIPSNAP antibody (ABIN6990879) specifically detects NIPSNAP in ELISA, WB, IF and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for NIPSNAP (AA 130-180) antibody (ABIN6990879)

Target: NIPSNAP

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 130-180

Purification: NIPSNAP Antibody is affinity chromatography purified via peptide column.

Immunogen: NIPSNAP antibody was raised against a 19 amino acid synthetic peptide from near the center of human NIPSNAP. The immunogen is located within amino acids 130 - 180 of NIPSNAP.

Isotype: IgG

Application Details

Application Notes: NIPSNAP antibody can be used for the detection of NIPSNAP by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NIPSNAP Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NIPSNAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details

Target: NIPSNAP

Background: NIPSNAP Antibody: NIPSNAP is a member of an evolutionarily well conserved gene family and has a strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. Recent studies have indicated that NIPSNAP is involved in the regulation of the Ca2+-selective transient receptor potential vanilloid channel 6 (TRPV6). NIPSNAP1 associates with TRPV6 at the plasma membrane and inhibits TRPV6 currents. Other studies show that NIPSNAP's expression is reduced in the phenylketonuria (PKU) mouse brain, suggesting that NIPSNAP may play a role in memory.

Gene ID: 8508

NCBI Accession: NP_003625

UniProt: Q9BPW8