COPS8 antibody (C-Term)

Catalog No. ABIN6990904

This Rabbit Polyclonal antibody specifically detects COPS8 in WB and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for COPS8 antibody (C-Term) (ABIN6990904)

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-COPS8 Antibody

Binding Specificity: C-Term

Purification: CSN8 Antibody is affinity chromatography purified via peptide column.

Immunogen: CSN8 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human CSN8. The immunogen is located within the last 50 amino acids of CSN8.

Isotype: IgG

Application Details

Application Notes: CSN8 antibody can be used for detection of CSN8 by Western blot at 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CSN8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CSN8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for COPS8

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Alternative Name: CSN8

Background: CSN8 Antibody: The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.

Gene ID: 10920

NCBI Accession: NP_006701

UniProt: Q99627

Pathways: Cell Division Cycle