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Syntaphilin antibody (AA 350-400)

SNPH Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990920
  • Target See all Syntaphilin (SNPH) Antibodies
    Syntaphilin (SNPH)
    Binding Specificity
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 350-400
    Reactivity
    • 13
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 10
    • 3
    Rabbit
    Clonality
    • 12
    • 1
    Polyclonal
    Conjugate
    • 9
    • 2
    • 1
    • 1
    This Syntaphilin antibody is un-conjugated
    Application
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    Syntaphilin Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Syntaphilin antibody was raised against a 16 amino acid synthetic peptide from near the center of human Syntaphilin. The immunogen is located within amino acids 350 - 400 of Syntaphilin.
    Isotype
    IgG
    Top Product
    Discover our top product SNPH Primary Antibody
  • Application Notes
    Syntaphilin antibody can be used for detection of Syntaphilin by Western blot at 1 - 2 μ,g/mL. Despite its predicted molecular weight, Syntaphilin usually migrates at higher molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Syntaphilin Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    Syntaphilin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    Syntaphilin (SNPH)
    Alternative Name
    Syntaphilin (SNPH Products)
    Synonyms
    bA314N13.5 antibody, 6430515A01 antibody, AW045671 antibody, AW556958 antibody, AW743098 antibody, mKIAA0374 antibody, syntaphilin antibody, SNPH antibody, Snph antibody
    Background
    Syntaphilin Antibody: Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.
    Gene ID
    9751
    UniProt
    O15079
    Pathways
    Synaptic Vesicle Exocytosis
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