BICD2 antibody (AA 300-350)

Catalog No. ABIN6990934

This Rabbit Polyclonal antibody specifically detects BICD2 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for BICD2 antibody (AA 300-350) (ABIN6990934)

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BICD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BICD2 Antibody

Binding Specificity: AA 300-350

Specificity: This BICD2 antibody will not cross-react with BICD1.

Purification: BICD2 Antibody is affinity chromatography purified via peptide column.

Immunogen: BICD2 antibody was raised against a 14 amino acid synthetic peptide from near the center of human BICD2. The immunogen is located within amino acids 300 - 350 of BICD2.

Isotype: IgG

Application Details

Application Notes: BICD2 antibody can be used for detection of BICD2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: BICD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: BICD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BICD2

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Alternative Name: BICD2

Background: BICD2 Antibody: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.

Molecular Weight: Predicted: 94 kDa

Observed: 100 kDa

Gene ID: 23299

UniProt: Q8TD16

Pathways: Maintenance of Protein Location