FERMT3 antibody (C-Term)

Catalog No. ABIN6990977

The Rabbit Polyclonal anti-FERMT3 antibody is suitable to detect FERMT3 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for FERMT3 antibody (C-Term) (ABIN6990977)

Target: FERMT3 (Fermitin Family Member 3 (FERMT3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FERMT3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FERMT3 Antibody

Binding Specificity: C-Term

Purification: KINDLIN3 Antibody is affinity chromatography purified via peptide column.

Immunogen: KINDLIN3 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of the human KINDLIN3. The immunogen is located within the last 50 amino acids of KINDLIN3.

Isotype: IgG

Application Details

Application Notes: KINDLIN3 antibody can be used for detection of KINDLIN3 by Western blot at 1 and 2 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KINDLIN3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KINDLIN3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for FERMT3

Target: FERMT3 (Fermitin Family Member 3 (FERMT3))

Alternative Name: KINDLIN3

Background: KINDLIN3 Antibody: The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.

Molecular Weight: Predicted: 73 kDa

Observed: 73 kDa

Gene ID: 83706

NCBI Accession: NP_848537

UniProt: Q86UX7