ZNF350 antibody (C-Term)

Catalog No. ABIN6990987

Product Details anti-ZNF350 Antibody

Target: ZNF350 (Zinc Finger Protein 350 (ZNF350))

Binding Specificity: AA 410-460, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF350 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: ZBRK1 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZBRK1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human ZBRK1. The immunogen is located within amino acids 410 - 460 of ZBRK1.

Isotype: IgG

Application Details

Application Notes: ZBRK1 antibody can be used for detection of ZBRK1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZBRK1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ZBRK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ZNF350

Target: ZNF350 (Zinc Finger Protein 350 (ZNF350))

Alternative Name: ZBRK1 (ZNF350 Products)

Synonyms: ZFQR antibody, ZBRK1 antibody, zinc finger protein 350 antibody, ZNF350 antibody, znf350 antibody

Background: ZBRK1 Antibody: ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.

Gene ID: 59348

NCBI Accession: NP_067645

UniProt: Q9GZX5