Junctophilin 2 antibody (C-Term)

Catalog No. ABIN6991022

The Rabbit Polyclonal anti-Junctophilin 2 antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect Junctophilin 2 in samples from Human, Mouse and Rat.

Quick Overview for Junctophilin 2 antibody (C-Term) (ABIN6991022)

Target: Junctophilin 2 (JPH2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Junctophilin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Junctophilin 2 Antibody

Binding Specificity: AA 470-520, C-Term

Purification: JPH2 Antibody is affinity chromatography purified via peptide column.

Immunogen: JPH2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human JPH2. The immunogen is located within amino acids 470 - 520 of JPH2.

Isotype: IgG

Application Details

Application Notes: JPH2 antibody can be used for detection of JPH2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: JPH2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: JPH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Junctophilin 2

Target: Junctophilin 2 (JPH2)

Alternative Name: JPH2

Background: JPH2 Antibody: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.

Gene ID: 84502

NCBI Accession: NP_065166

UniProt: Q96JJ6