ATOH8 antibody (C-Term)

Catalog No. ABIN6991090

This Rabbit Polyclonal antibody specifically detects ATOH8 in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ATOH8 antibody (C-Term) (ABIN6991090)

Target: ATOH8 (Atonal Homolog 8 (ATOH8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATOH8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ATOH8 Antibody

Binding Specificity: C-Term

Purification: ATOH8 Antibody is affinity chromatography purified via peptide column.

Immunogen: ATOH8 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ATOH8. The immunogen is located within the last 50 amino acids of ATOH8.

Isotype: IgG

Application Details

Application Notes: ATOH8 antibody can be used for detection of ATOH8 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATOH8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ATOH8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ATOH8

Target: ATOH8 (Atonal Homolog 8 (ATOH8))

Alternative Name: ATOH8

Background: ATOH8 Antibody: Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57 % identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.

Molecular Weight: Predicted: 35 kDa

Observed: 40 kDa

Gene ID: 84913

NCBI Accession: NP_116216

UniProt: Q96SQ7

Pathways: Regulation of Muscle Cell Differentiation