TTR antibody (AA 40-90)

Catalog No. ABIN6991113

This anti-TTR antibody is a Chicken Polyclonal antibody detecting TTR in WB, ELISA, IF and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for TTR antibody (AA 40-90) (ABIN6991113)

Target: TTR (Transthyretin (TTR))

Reactivity: Human, Mouse, Rat

Host: Chicken

Clonality: Polyclonal

Conjugate: This TTR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TTR Antibody

Binding Specificity: AA 40-90

Purification: Transthyretin Antibody is affinity chromatography purified via peptide column.

Immunogen: Transthyretin antibody was raised against a 17 amino acid synthetic peptide near the center of human Transthyretin. The immunogen is located within amino acids 40 - 90 of Transthyretin.

Isotype: IgY

Application Details

Application Notes: Transthyretin antibody can be used for detection of Transthyretin by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Transthyretin Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Transthyretin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: Transthyretin

Background: Transthyretin Antibody: Transthyretin is a tetrameric carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. More than 80 different mutations in this gene have been reported, most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include familial amyloidotic polyneuropathy, euthyroid hyperthyroxinemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. It has also been suggested that Transthyretin plays an important role in the maintenance of normal cognitive processes during aging, neuropeptide processing and nerve regeneration. It has also been linked to several pathological conditions including Parkinson's disease, schizophrenia, and depression.

Molecular Weight: Predicted: 15 kDa

Observed: 16 kDa

Gene ID: 7276

UniProt: P02766

Pathways: Hormone Transport