RGS21 antibody (AA 40-90)

Catalog No. ABIN6991130

Product Details anti-RGS21 Antibody

Target: RGS21 (Regulator of G-Protein Signaling 21 (RGS21))

Binding Specificity: AA 40-90

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS21 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: RGS21 Antibody is affinity chromatography purified via peptide column.

Immunogen: RGS21 antibody was raised against a 16 amino acid synthetic peptide near the center of human RGS21. The immunogen is located within amino acids 40 - 90 of RGS21.

Isotype: IgG

Application Details

Application Notes: RGS21 antibody can be used for detection of RGS21 by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: RGS21 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: RGS21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RGS21

Target: RGS21 (Regulator of G-Protein Signaling 21 (RGS21))

Alternative Name: RGS21 (RGS21 Products)

Synonyms: EG624910 antibody, regulator of G protein signaling 21 antibody, regulator of G-protein signaling 21 antibody, regulator of G-protein signalling 21 antibody, RGS21 antibody, Rgs21 antibody

Background: RGS21 Antibody: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS21 is a recently identified member of this family that has been reported to be selectively expressed in subpopulations of taste bud cells and co-expressed with bitter and sweet transduction components such as alpha-gusticin, phospholipase Cbeta2, T1R2/T1R3 sweet taste receptors and T2R bitter taste receptors. Other reports indicate that RGS21 is more widely expressed. Binding assays demonstrate that RGS21 binds alpha-gusticin in a conformation-dependent manner and may do the same with T1R receptors, suggesting that RGS21 may play a role in sweet and bitter taste transduction processes.

Gene ID: 431704

NCBI Accession: NP_001034241

UniProt: Q2M5E4

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling