RANBP10 antibody (AA 380-430)

Catalog No. ABIN6991302

This anti-RANBP10 antibody is a Rabbit Polyclonal antibody detecting RANBP10 in WB, ELISA, IHC (p) and IF. Suitable for Human.

Quick Overview for RANBP10 antibody (AA 380-430) (ABIN6991302)

Target: RANBP10 (RAN Binding Protein 10 (RANBP10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RANBP10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-RANBP10 Antibody

Binding Specificity: AA 380-430

Purification: RANBP10 Antibody is affinity chromatography purified via peptide column.

Immunogen: RANBP10 antibody was raised against a 15 amino acid synthetic peptide near the center of human RANBP10. The immunogen is located within amino acids 380 - 430 of RANBP10.

Isotype: IgG

Application Details

Application Notes: RANBP10 antibody can be used for detection of RANBP10 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: RANBP10 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: RANBP10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RANBP10

Target: RANBP10 (RAN Binding Protein 10 (RANBP10))

Alternative Name: RANBP10

Background: RANBP10 Antibody: The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.

Gene ID: 57610

UniProt: Q6VN20