ANAPC11 antibody (AA 70-120)

Catalog No. ABIN6991330

This Rabbit Polyclonal antibody specifically detects ANAPC11 in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ANAPC11 antibody (AA 70-120) (ABIN6991330)

Target: ANAPC11 (Anaphase Promoting Complex Subunit 11 (ANAPC11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANAPC11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-ANAPC11 Antibody

Binding Specificity: AA 70-120

Purification: APC11 Antibody is affinity chromatography purified via peptide column.

Immunogen: APC11 antibody was raised against an 18 amino acid synthetic peptide near the center of human APC11. The immunogen is located within amino acids 70 - 120 of APC11.

Isotype: IgG

Application Details

Application Notes: APC11 antibody can be used for detection of APC11 by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: APC11 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: APC11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ANAPC11

Target: ANAPC11 (Anaphase Promoting Complex Subunit 11 (ANAPC11))

Alternative Name: APC11

Background: APC11 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC11 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC11, together with APC2 and Ubc4, form the minimal APC ubiquitin ligase module.

Molecular Weight: Predicted: 22 kDa

Observed: 22 kDa

Gene ID: 51529

NCBI Accession: NP_001002244

UniProt: Q9NYG5