TCTN2 antibody (C-Term)

Catalog No. ABIN6991370

Product Details anti-TCTN2 Antibody

Target: TCTN2 (Tectonic Family Member 2 (TCTN2))

Binding Specificity: AA 610-660, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCTN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: TCTN2 Antibody is affinity chromatography purified via peptide column.

Immunogen: TCTN2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TCTN2. The immunogen is located within amino acids 610 - 660 of TCTN2.

Isotype: IgG

Application Details

Application Notes: TCTN2 antibody can be used for detection of TCTN2 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TCTN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TCTN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TCTN2

Target: TCTN2 (Tectonic Family Member 2 (TCTN2))

Alternative Name: TCTN2 (TCTN2 Products)

Synonyms: fb44f11 antibody, wu:fb44f11 antibody, tect2 antibody, C12orf38 antibody, MKS8 antibody, TECT2 antibody, 4432405B04Rik antibody, Tect2 antibody, tectonic family member 2 antibody, TCTN2 antibody, tctn2 antibody, Tctn2 antibody

Background: TCTN2 Antibody: TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49 % similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

Gene ID: 79867

NCBI Accession: NP_079085

UniProt: Q96GX1

Pathways: Proton Transport