TCTN3 antibody (C-Term)

Catalog No. ABIN6991371

Product Details anti-TCTN3 Antibody

Target: TCTN3 (Tectonic Family Member 3 (TCTN3))

Binding Specificity: AA 540-590, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCTN3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: TCTN3 Antibody is affinity chromatography purified via peptide column.

Immunogen: TCTN3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human TCTN3. The immunogen is located within amino acids 540 - 590 of TCTN3.

Isotype: IgG

Application Details

Application Notes: TCTN3 antibody can be used for detection of TCTN3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 4 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TCTN3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TCTN3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TCTN3

Target: TCTN3 (Tectonic Family Member 3 (TCTN3))

Alternative Name: TCTN3 (TCTN3 Products)

Synonyms: RGD1305166 antibody, C10orf61 antibody, JBTS18 antibody, OFD4 antibody, TECT3 antibody, 4930521E07Rik antibody, AI197391 antibody, Tect3 antibody, tectonic family member 3 antibody, Tctn3 antibody, TCTN3 antibody

Background: TCTN3 Antibody: TCTN3 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN3 is not known, it is 58 % similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

Gene ID: 26123

NCBI Accession: NP_056446

UniProt: Q6NUS6