SCUBE1 antibody (AA 460-510)

Catalog No. ABIN6991373

Product Details anti-SCUBE1 Antibody

Target: SCUBE1 (Signal Peptide, CUB Domain, EGF-Like 1 (SCUBE1))

Binding Specificity: AA 460-510

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCUBE1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Purification: SCUBE1 Antibody is affinity chromatography purified via peptide column.

Immunogen: SCUBE1 antibody was raised against a 14 amino acid synthetic peptide near the center of human SCUBE1. The immunogen is located within amino acids 460 - 510 of SCUBE1.

Isotype: IgG

Application Details

Application Notes: SCUBE1 antibody can be used for detection of SCUBE1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SCUBE1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SCUBE1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SCUBE1

Target: SCUBE1 (Signal Peptide, CUB Domain, EGF-Like 1 (SCUBE1))

Alternative Name: SCUBE1 (SCUBE1 Products)

Synonyms: 7330410C13Rik antibody, A630023E24Rik antibody, signal peptide, CUB domain and EGF like domain containing 1 antibody, signal peptide, CUB domain, EGF-like 1 antibody, SCUBE1 antibody, Scube1 antibody

Background: SCUBE1 Antibody: SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity, genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.

Gene ID: 80274

NCBI Accession: NP_766638

UniProt: Q8IWY4