SCUBE2 antibody (AA 480-530)

Catalog No. ABIN6991374

This anti-SCUBE2 antibody is a Rabbit Polyclonal antibody detecting SCUBE2 in ELISA, WB, IF and ICC. Suitable for Human and Rat.

Quick Overview for SCUBE2 antibody (AA 480-530) (ABIN6991374)

Target: SCUBE2 (Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCUBE2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-SCUBE2 Antibody

Binding Specificity: AA 480-530

Purification: SCUBE2 Antibody is affinity chromatography purified via peptide column.

Immunogen: SCUBE2 antibody was raised against a 17 amino acid synthetic peptide near the center of human SCUBE2. The immunogen is located within amino acids 480 - 530 of SCUBE2.

Isotype: IgG

Application Details

Application Notes: SCUBE2 antibody can be used for detection of SCUBE2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SCUBE2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SCUBE2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SCUBE2

Target: SCUBE2 (Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2))

Alternative Name: SCUBE2

Background: SCUBE2 Antibody: SCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.

Gene ID: 57758

NCBI Accession: NP_066025

UniProt: Q9NQ36