SCUBE2 antibody (Center)

Catalog No. ABIN783651

Product Details anti-SCUBE2 Antibody

Target: SCUBE2 (Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2))

Binding Specificity: Center

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCUBE2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the center of human SCUBE2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for SCUBE2

Target: SCUBE2 (Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2))

Alternative Name: SCUBE2 (SCUBE2 Products)

Synonyms: CEGB1 antibody, CEGF1 antibody, CEGP1 antibody, 4932442O19Rik antibody, Cegf1 antibody, Cegp1 antibody, RGD1563998 antibody, Scube2-ps1 antibody, wu:fc27f08 antibody, you antibody, signal peptide, CUB domain and EGF like domain containing 2 antibody, signal peptide, CUB domain, EGF-like 2 antibody, SCUBE2 antibody, Scube2 antibody, scube2 antibody

Background: SCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.Synonyms: CEGP1, Signal peptide CUB and EGF-like domain-containing protein 2

Gene ID: 57758

NCBI Accession: NP_001164161

UniProt: Q9NQ36