CCDC106 antibody (C-Term)

Catalog No. ABIN6991384

This Rabbit Polyclonal antibody specifically detects CCDC106 in ELISA, WB, IHC (p) and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CCDC106 antibody (C-Term) (ABIN6991384)

Target: CCDC106 (Coiled-Coil Domain Containing 106 (CCDC106))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC106 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-CCDC106 Antibody

Binding Specificity: C-Term

Purification: CCDC106 Antibody is affinity chromatography purified via peptide column.

Immunogen: CCDC106 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human CCDC106. The immunogen is located within the last 50 amino acids of CCDC106.

Isotype: IgG

Application Details

Application Notes: CCDC106 antibody can be used for detection of CCDC106 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CCDC106 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CCDC106 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CCDC106

Target: CCDC106 (Coiled-Coil Domain Containing 106 (CCDC106))

Alternative Name: CCDC106

Background: CCDC106 Antibody: The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.

Gene ID: 29903

NCBI Accession: NP_037433

UniProt: Q9BWC9