PEAR1 antibody (C-Term)

Catalog No. ABIN6991445

The Rabbit Polyclonal anti-PEAR1 antibody has been validated for ELISA, WB, IHC (p) and IF. It is suitable to detect PEAR1 in samples from Human, Mouse and Rat.

Quick Overview for PEAR1 antibody (C-Term) (ABIN6991445)

Target: PEAR1 (Platelet Endothelial Aggregation Receptor 1 (PEAR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEAR1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-PEAR1 Antibody

Binding Specificity: C-Term

Purification: PEAR1 Antibody is affinity chromatography purified via peptide column.

Immunogen: PEAR1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human PEAR1. The immunogen is located within the last 50 amino acids of PEAR1.

Isotype: IgG

Application Details

Application Notes: PEAR1 antibody can be used for detection of PEAR1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PEAR1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PEAR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PEAR1

Target: PEAR1 (Platelet Endothelial Aggregation Receptor 1 (PEAR1))

Alternative Name: PEAR1

Background: PEAR1 Antibody: Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated, the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.

Gene ID: 375033

NCBI Accession: NP_001073940

UniProt: Q5VY43