TM4SF1 antibody (N-Term)

Catalog No. ABIN6991504

Product Details anti-TM4SF1 Antibody

Target: TM4SF1 (Transmembrane 4 L Six Family Member 1 (TM4SF1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TM4SF1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: At least three isoforms of TM4SF1 are known to exist, this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.

Purification: TM4SF1 Antibody is affinity chromatography purified via peptide column.

Immunogen: TM4SF1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TM4SF1. The immunogen is located within the first 50 amino acids of TM4SF1.

Isotype: IgG

Application Details

Application Notes: TM4SF1 antibody can be used for detection of TM4SF1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TM4SF1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TM4SF1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TM4SF1

Target: TM4SF1 (Transmembrane 4 L Six Family Member 1 (TM4SF1))

Alternative Name: TM4SF1 (TM4SF1 Products)

Synonyms: MGC85546 antibody, h-l6 antibody, m3s1 antibody, taal6 antibody, H-L6 antibody, L6 antibody, M3S1 antibody, TAAL6 antibody, MM3 antibody, M3s1 antibody, transmembrane 4 L six family member 1 antibody, transmembrane 4 L six family member 1 S homeolog antibody, transmembrane 4 superfamily member 1 antibody, TM4SF1 antibody, tm4sf1.S antibody, tm4sf1 antibody, Tm4sf1 antibody

Background: TM4SF1 Antibody: TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.

Gene ID: 4071

NCBI Accession: NP_055035

UniProt: P30408