ORMDL1 antibody (AA 50-100)

Catalog No. ABIN6991534

This Rabbit Polyclonal antibody specifically detects ORMDL1 in ELISA, WB, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ORMDL1 antibody (AA 50-100) (ABIN6991534)

Target: ORMDL1 (ORM1-Like 1 (ORMDL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORMDL1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ORMDL1 Antibody

Binding Specificity: AA 50-100

Specificity: ORMDL1 antibody may cross-react with other ORMDL protein family members.

Purification: ORMDL1 Antibody is affinity chromatography purified via peptide column.

Immunogen: ORMDL1 antibody was raised against a 16 amino acid synthetic peptide of human ORMDL1. The immunogen is located within amino acids 50 - 100 of ORMDL1.

Isotype: IgG

Application Details

Application Notes: ORMDL1 antibody can be used for detection of ORMDL1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ORMDL1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: ORMDL1 antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ORMDL1

Target: ORMDL1 (ORM1-Like 1 (ORMDL1))

Alternative Name: ORMDL1

Background: ORMDL1 Antibody: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD). Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.

Gene ID: 94101

NCBI Accession: NP_057551

UniProt: Q9P0S3