Anosmin antibody (AA 430-480)

Catalog No. ABIN6991537

This Rabbit Polyclonal antibody specifically detects Anosmin in WB, ELISA, ICC and IF. It exhibits reactivity toward Human.

Quick Overview for Anosmin antibody (AA 430-480) (ABIN6991537)

Target: Anosmin (ANOS1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Anosmin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-Anosmin Antibody

Binding Specificity: AA 430-480

Purification: Anosmin Antibody is affinity chromatography purified via peptide column.

Immunogen: Anosmin antibody was raised against an 18 amino acid synthetic peptide near the center of human Anosmin. The immunogen is located within amino acids 430 - 480 of Anosmin.

Isotype: IgG

Application Details

Application Notes: Anosmin antibody can be used for detection of Anosmin by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Anosmin Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Anosmin antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Anosmin

Target: Anosmin (ANOS1)

Alternative Name: Anosmin

Background: Anosmin Antibody: Mutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.

Gene ID: 3730

NCBI Accession: NP_000207

UniProt: P23352