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DRAXIN antibody (C-Term)

This anti-DRAXIN antibody is a Rabbit Polyclonal antibody detecting DRAXIN in WB, ELISA, IHC (p) and IF. Suitable for Human, Mouse and Rat.
Catalog No. ABIN6991584

Quick Overview for DRAXIN antibody (C-Term) (ABIN6991584)

Target

See all DRAXIN Antibodies
DRAXIN (Dorsal Inhibitory Axon Guidance Protein (DRAXIN))

Reactivity

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Human, Mouse, Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This DRAXIN antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
  • Binding Specificity

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    C-Term

    Specificity

    At least three isoforms of Neucrin are known to exist, this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.

    Purification

    NEUCRIN Antibody is affinity chromatography purified via peptide column.

    Immunogen

    Neucrin antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Neucrin. The immunogen is located within the last 50 amino acids of NEUCRIN.

    Isotype

    IgG
  • Application Notes

    Neucrin antibody can be used for detection of Neucrin by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    NEUCRIN Antibody is supplied in PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    NEUCRIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    DRAXIN (Dorsal Inhibitory Axon Guidance Protein (DRAXIN))

    Alternative Name

    NEUCRIN

    Background

    NEUCRIN Antibody: Neucrin, also known as Draxin, is a repulsive guidance protein for the spinal cord and forebrain commissures. It is thought to act as an antagonist of canonical Wnt signaling by inhibiting the stabilization of cytosolic beta-catenin. Ectopically expressed neucrin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo while Neucrin-null mice showed defasciculation of spinal cord commissural axons and an absence of all forebrain commisures. Other experiments in mice have shown that olfactory bulb axonal outgrowth is inhibited by Neucrin, suggesting that Neucrin functions as an inhibitory guidance cue for olfactory bulb axons.

    Gene ID

    374946

    UniProt

    Q8NBI3
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