DRAXIN antibody (C-Term)

Catalog No. ABIN1450058

The Rabbit Polyclonal anti-DRAXIN antibody is suitable to detect DRAXIN in samples from Human, Mouse and Rat. It has been validated for WB, IHC (p), IF and EIA.

Quick Overview for DRAXIN antibody (C-Term) (ABIN1450058)

Target: DRAXIN (Dorsal Inhibitory Axon Guidance Protein (DRAXIN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRAXIN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-DRAXIN Antibody

Binding Specificity: C-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid synthetic peptide near the carboxy terminus of Human Neucrin

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DRAXIN

Target: DRAXIN (Dorsal Inhibitory Axon Guidance Protein (DRAXIN))

Alternative Name: Draxin

Background: Neucrin, also known as Draxin, is a repulsive guidance protein for the spinal cord and forebrain commissures. It is thought to act as an antagonist of canonical Wnt signaling by inhibiting the stabilization of cytosolic beta-catenin. Ectopically expressed neucrin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo while Neucrin-null mice showed defasciculation of spinal cord commissural axons and an absence of all forebrain commisures. Other experiments in mice have shown that olfactory bulb axonal outgrowth is inhibited by Neucrin, suggesting that Neucrin functions as an inhibitory guidance cue for olfactory bulb axons.Synonyms: C1orf187, Dorsal repulsive axon guidance protein, Neucrin, PSEC0258

Gene ID: 374946