AFAP antibody (N-Term)
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- Target See all AFAP (AFAP1) Antibodies
- AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))
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Binding Specificity
- AA 30-80, N-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AFAP antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- Monomer and homomultimer of AFAP1 are known to exist, AFAP1 antibody is predicted to not cross-react with other AFAP family members.
- Purification
- AFAP1 Antibody is affinity chromatography purified via peptide column.
- Immunogen
- AFAP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human AFAP1. The immunogen is located within amino acids 30 - 80 of AFAP1.
- Isotype
- IgG
- Top Product
- Discover our top product AFAP1 Primary Antibody
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- Application Notes
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AFAP1 antibody can be used for detection of AFAP1 by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- AFAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,4 °C
- Storage Comment
- AFAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))
- Alternative Name
- AFAP1 (AFAP1 Products)
- Synonyms
- afap antibody, afap-110 antibody, AFAP antibody, AFAP-110 antibody, AFAP110 antibody, 2600003E23Rik antibody, 9630044L16Rik antibody, AI848729 antibody, Afap antibody, mKIAA3018 antibody, actin filament associated protein 1 antibody, AFAP1 antibody, afap1 antibody, Afap1 antibody
- Background
- AFAP1 Antibody: The actin filament-associated protein AFAP1 (AFAP-110) is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP1 has a fundamental role in actin cytoskeleton arrangement. It contains a carboxyterminal actin-binding domain that directly binds to F-actin and serves as an adaptor protein in the regulation of SRC and PKC signal transduction by several functional domains, including 2 pleckstrin homology (PH) domains, a Src homology 3-binding (SH3-binding) motif, and several SH2-binding motifs. It is overexpressed in prostate carcinoma and contributes to tumor growth by regulating cell-matrix adhesions and migration in the cancer cells. AFAP1 represent a possible therapeutic target for controlling tumorigenesis and metastasis.
- Gene ID
- 60312
- NCBI Accession
- NP_940997
- UniProt
- Q8N556
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