CASKIN2 antibody (N-Term)

Catalog No. ABIN6991638

Product Details anti-CASKIN2 Antibody

Target: CASKIN2 (CASK Interacting Protein 2 (CASKIN2))

Binding Specificity: AA 380-430, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASKIN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: CASKIN2 antibody is predicted to not cross-react with other CASKIN family members. Three isoforms of CASKIN2 are known to exist, this antibody will not detect the shortest isoform.

Purification: CASKIN2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CASKIN2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human CASKIN2. The immunogen is located within amino acids 380 - 430 of CASKIN2.

Isotype: IgG

Application Details

Application Notes: CASKIN2 antibody can be used for detection of EPAC1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CASKIN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CASKIN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CASKIN2

Target: CASKIN2 (CASK Interacting Protein 2 (CASKIN2))

Alternative Name: CASKIN2 (CASKIN2 Products)

Synonyms: anks5b antibody, MGC98998 antibody, ANKS5B antibody, 1600028L06Rik antibody, mKIAA1139 antibody, CASK interacting protein 2 antibody, cask-interacting protein 2 antibody, CASK interacting protein 2 L homeolog antibody, CASK-interacting protein 2 antibody, CASKIN2 antibody, Caskin2 antibody, caskin2.L antibody

Background: CASKIN2 Antibody: Calcium/calmodulin-dependent serine protein kinase (CASK) is a conserved multi-domain scaffolding protein involved in brain development, synapse formation, and establishment of cell polarity. CASKINs (CASK interacting protein ) interact with CASK and is thought to play a role in CASK function, specifically by coupling CASK to distinct downstream effectors. CASKIN2 is a multidomain protein containing six N-terminal ankyrin repeats, one SH3 domain, and two sterile alpha motif domains followed by a long proline-rich sequence and a short conserved C-terminal domain. It is expressed ubiquitously with highest levels present in fetal and adult liver tissue.

Molecular Weight: Predicted: 123, 132 kDa

Observed: 120 kDa

Gene ID: 57513

NCBI Accession: NP_065804

UniProt: Q8WXE0