C9ORF116 antibody (N-Term)

Catalog No. ABIN6991649

The Rabbit Polyclonal anti-C9ORF116 antibody is suitable to detect C9ORF116 in samples from Human and Mouse. It has been validated for WB, ELISA and ICC.

Quick Overview for C9ORF116 antibody (N-Term) (ABIN6991649)

Target: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C9ORF116 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-C9ORF116 Antibody

Binding Specificity: N-Term

Specificity: PIERCE1 antibody is predicted to not cross-react with other UPF0691 family members.

Purification: PIERCE1 Antibody is affinity chromatography purified via peptide column.

Immunogen: PIERCE1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human PIERCE1. The immunogen is located within the first 50 amino acids of PIERCE1.

Isotype: IgG

Application Details

Application Notes: PIERCE1 antibody can be used for detection of PIERCE1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PIERCE1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PIERCE1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for C9ORF116

Target: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Alternative Name: PIERCE1

Background: PIERCE1 Antibody: PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.

Gene ID: 138162

UniProt: Q5BN46