ESRRB antibody (C-Term)

Catalog No. ABIN6991681

This Rabbit Polyclonal antibody specifically detects ESRRB in WB, ELISA, IHC (p) and IF. It exhibits reactivity toward Human.

Quick Overview for ESRRB antibody (C-Term) (ABIN6991681)

Target: ESRRB (Estrogen-Related Receptor beta (ESRRB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESRRB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-ESRRB Antibody

Binding Specificity: AA 360-410, C-Term

Purification: ESRRB Antibody is affinity chromatography purified via peptide column.

Immunogen: ESRRB antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ESRRB. The immunogen is located within amino acids 360 - 410 of ESRRB.

Isotype: IgG

Application Details

Application Notes: ESRRB antibody can be used for detection of ESRRB by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ESRRB Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ESRRB antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ESRRB

Target: ESRRB (Estrogen-Related Receptor beta (ESRRB))

Alternative Name: ESRRB

Background: ESRRB Antibody: The estrogen-related receptor beta (ESRRB) was initially identified in mouse embryonic carcinoma stem cells and was found to be expressed exclusively in trophoblast progenitor cells between days 6.5 and 7.5 post coitum. Recent studies have shown that ESRRB is part of an POU5F1/Oct4-centered protein interaction network in embryonic stem (ES) cells. It is thought to interact with other ES transcription factors such as NANOG within this network, activating POU5F1 transcription and thereby sustaining self-renewal and pluripotency in ES cells.

Gene ID: 2103

NCBI Accession: NP_004443

UniProt: O95718

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance