DELE1/KIAA0141 antibody (N-Term)

Catalog No. ABIN6991710

Product Details anti-DELE1/KIAA0141 Antibody

Target: DELE1/KIAA0141 (DELE1) (DAP3 Binding Cell Death Enhancer 1 (DELE1))

Binding Specificity: N-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DELE1/KIAA0141 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: DELE Antibody is affinity chromatography purified via peptide column.

Immunogen: DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE. The immunogen is located within the first 50 amino acids of DELE.

Isotype: IgG

Application Details

Application Notes: DELE antibody can be used for detection of DELE by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DELE Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DELE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DELE1/KIAA0141

Target: DELE1/KIAA0141 (DELE1) (DAP3 Binding Cell Death Enhancer 1 (DELE1))

Alternative Name: DELE (DELE1 Products)

Synonyms: KIAA0141 antibody, MGC139304 antibody, DELE antibody, 2700004E22Rik antibody, Dele antibody, Kiaa0141 antibody, KIAA0141 antibody, KIAA0141 ortholog antibody, RIKEN cDNA 0610009O20 gene antibody, SEL1 domain containing protein RGD735029 antibody, KIAA0141 antibody, 0610009O20Rik antibody, RGD735029 antibody

Background: DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α, and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

Gene ID: 9812

NCBI Accession: NP_055588

UniProt: Q14154