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PLA1A antibody (C-Term)

PLA1A Reactivity: Human, Rat WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991764
  • Target See all PLA1A Antibodies
    PLA1A (Phospholipase A1 Member A (PLA1A))
    Binding Specificity
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 380-430, C-Term
    Reactivity
    • 35
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 31
    • 4
    Rabbit
    Clonality
    • 34
    • 1
    Polyclonal
    Conjugate
    • 18
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PLA1A antibody is un-conjugated
    Application
    • 24
    • 16
    • 13
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Specificity
    At least three isoforms of PLA1A are known to exist, this antibody will detect all three isoforms.
    Purification
    PLA1A Antibody is affinity chromatography purified via peptide column.
    Immunogen
    PLA1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human PLA1A. The immunogen is located within amino acids 380 - 430 of PLA1A.
    Isotype
    IgG
    Top Product
    Discover our top product PLA1A Primary Antibody
  • Application Notes
    PLA1A antibody can be used for detection of PLA1A by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PLA1A Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    PLA1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    PLA1A (Phospholipase A1 Member A (PLA1A))
    Alternative Name
    PLA1A (PLA1A Products)
    Synonyms
    PS-PLA1 antibody, PSPLA1 antibody, AA986889 antibody, Ps-pla1 antibody, Pspla1 antibody, wu:fi26h09 antibody, zgc:77160 antibody, AH antibody, ARWH2 antibody, LAH2 antibody, LPDLR antibody, PLA1B antibody, mPA-PLA1 antibody, phospholipase A1 member A antibody, lipase H antibody, PLA1A antibody, Pla1a antibody, pla1a antibody, CpipJ_CPIJ002492 antibody, CpipJ_CPIJ007883 antibody, LIPH antibody
    Background
    PLA1A Antibody: PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.
    Molecular Weight
    50 kDa
    Gene ID
    51365
    NCBI Accession
    NP_056984
    UniProt
    Q53H76
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