PANX1 antibody (N-Term)

Catalog No. ABIN6991780

This Rabbit Polyclonal antibody specifically detects PANX1 in WB, ELISA and IF. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for PANX1 antibody (N-Term) (ABIN6991780)

Target: PANX1 (Pannexin 1 (PANX1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PANX1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-PANX1 Antibody

Binding Specificity: AA 70-120, N-Term

Specificity: Two transcript variants encoding different isoforms have been found for this gene.

Purification: PANX1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal PANX1 antibody was raised against a 17 amino acid peptide near the amino terminus of human PANX1. The immunogen is located within amino acids 70 - 120 of PANX1.

Isotype: IgG

Application Details

Application Notes: PANX1 antibody can be used for detection of PANX1 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PANX1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PANX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PANX1

Target: PANX1 (Pannexin 1 (PANX1))

Alternative Name: PANX1

Background: PANX1 Antibody: The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.

Molecular Weight: 47 kDa

Gene ID: 24145

NCBI Accession: NP_056183

UniProt: Q96RD7