CHCHD6 antibody (N-Term)

Catalog No. ABIN6991790

The Rabbit Polyclonal anti-CHCHD6 antibody is suitable to detect CHCHD6 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for CHCHD6 antibody (N-Term) (ABIN6991790)

Target: CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHCHD6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CHCHD6 Antibody

Binding Specificity: AA 20-70, N-Term

Specificity: CHCHD6 is predicted to not cross-react to other members of the CHCHD family.

Purification: CHCHD6 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6. The immunogen is located within amino acids 20 - 70 of CHCHD6.

Isotype: IgG

Application Details

Application Notes: CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CHCHD6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CHCHD6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for CHCHD6

Target: CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))

Alternative Name: CHCHD6

Background: CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Molecular Weight: Predicted: 26 kDa

Gene ID: 84303

NCBI Accession: NP_115719

UniProt: Q9BRQ6