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CHCHD6 antibody (N-Term)

CHCHD6 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991790
  • Target See all CHCHD6 Antibodies
    CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))
    Binding Specificity
    • 15
    • 7
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    AA 20-70, N-Term
    Reactivity
    • 20
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 35
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 11
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CHCHD6 antibody is un-conjugated
    Application
    • 35
    • 17
    • 13
    • 13
    • 4
    • 3
    • 3
    Western Blotting (WB), ELISA
    Specificity
    CHCHD6 is predicted to not cross-react to other members of the CHCHD family.
    Purification
    CHCHD6 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6. The immunogen is located within amino acids 20 - 70 of CHCHD6.
    Isotype
    IgG
    Top Product
    Discover our top product CHCHD6 Primary Antibody
  • Application Notes
    CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    CHCHD6 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    CHCHD6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))
    Alternative Name
    CHCHD6 (CHCHD6 Products)
    Synonyms
    CHCM1 antibody, PPP1R23 antibody, 0710001P09Rik antibody, 1700021B03Rik antibody, chchd6 antibody, hm:zeh0124 antibody, zgc:91802 antibody, coiled-coil-helix-coiled-coil-helix domain containing 6 antibody, coiled-coil-helix-coiled-coil-helix domain containing 6a antibody, CHCHD6 antibody, Chchd6 antibody, chchd6a antibody
    Background
    CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
    Molecular Weight
    Predicted: 26 kDa
    Gene ID
    84303
    NCBI Accession
    NP_115719
    UniProt
    Q9BRQ6
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