TYK2 antibody (N-Term)

Catalog No. ABIN6991802

The Rabbit Polyclonal anti-TYK2 antibody has been validated for WB, ELISA and IF. It is suitable to detect TYK2 in samples from Human, Mouse and Rat.

Quick Overview for TYK2 antibody (N-Term) (ABIN6991802)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-TYK2 Antibody

Binding Specificity: AA 90-140, N-Term

Specificity: At least three isoforms of TYK2 are known to exist, this antibody only detects the two longest isoforms.

Purification: TYK2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2. The immunogen is located within amino acids 90 - 140 of TYK2.

Isotype: IgG

Application Details

Application Notes: TYK2 antibody can be used for detection of TYK2 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TYK2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TYK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: TYK2

Background: TYK2 Antibody: TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Molecular Weight: Predicted: 131 kDa

Gene ID: 7297

NCBI Accession: NP_003322

UniProt: P29597

Pathways: JAK-STAT Signaling, Hepatitis C