FOXA1 antibody (AA 270-320)

Catalog No. ABIN6991829

The Rabbit Polyclonal anti-FOXA1 antibody has been validated for WB and ELISA. It is suitable to detect FOXA1 in samples from Human.

Quick Overview for FOXA1 antibody (AA 270-320) (ABIN6991829)

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FOXA1 Antibody

Binding Specificity: AA 270-320

Specificity: Multiple isoforms of FOXA1 exists as a result of alternative splicing event.

Purification: FOXA1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal FOXA1 antibody was raised against a 17 amino acid peptide near the center of human FOXA1. The immunogen is located within amino acids 270 - 320 of FOXA1.

Isotype: IgG

Application Details

Application Notes: FOXA1 antibody can be used for detection of FOXA1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: FOXA1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: FOXA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for FOXA1

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Alternative Name: FOXA1

Background: FOXA1 Antibody: FOXA1 is one of three members of the FOXA family, a subset of the forkhead family of transcription factors which play vital roles in development. It has also been implicated in the development of a number of other organs including the androgen and estrogen regulated tissues of the breast and prostate. FOXA1 modulates the transcriptional activity of nuclear hormone receptors and regulates apoptosis by inhibiting the expression of BCL-2. It is an essential protein for the transcriptional activity of both androgen receptor (AR) and estrogen receptor-α, (ER). FOXA1 plays a pivotal role from early stage cancer through to drug resistant and metastatic disease. FOXA1 is not only an attractive therapeutic target but could potentially function as a novel biomarker.

Molecular Weight: 52 kDa

Gene ID: 3169

NCBI Accession: NP_004487

UniProt: P55317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis