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KREMEN2 antibody (C-Term)

The Rabbit Polyclonal anti-KREMEN2 antibody has been validated for WB, ELISA and ICC. It is suitable to detect KREMEN2 in samples from Human, Mouse and Rat.
Catalog No. ABIN6991832

Quick Overview for KREMEN2 antibody (C-Term) (ABIN6991832)

Target

See all KREMEN2 Antibodies
KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Reactivity

Human, Mouse, Rat

Host

  • 27
  • 3
Rabbit

Clonality

  • 30
Polyclonal

Conjugate

  • 10
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This KREMEN2 antibody is un-conjugated

Application

  • 30
  • 13
  • 13
  • 13
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
  • Binding Specificity

    • 15
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 390-440, C-Term

    Specificity

    Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.

    Purification

    KREMEN2 Antibody is affinity chromatography purified via peptide column.

    Immunogen

    Anti-KREMEN2 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human KREMEN2. The immunogen is located within amino acids 390-440 of KREMEN2.

    Isotype

    IgG
  • Application Notes

    WB: 1-2 μ,g/mL, ICC: 5 μ,g/mL.

    Antibody validated: Western Blot in human, mouse and rat samples, Immunocytochemistry in human samples. All other applications and species not yet tested.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    KREMEN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    KREMEN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target

    KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

    Alternative Name

    KREMEN2

    Background

    KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

    Molecular Weight

    Predicted: 49kD

    Observed: 49kD kDa

    Gene ID

    79412

    NCBI Accession

    NP_757384

    UniProt

    Q8NCW0

    Pathways

    WNT Signaling
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