IL17RA antibody (N-Term)

Catalog No. ABIN6991881

This anti-IL17RA antibody is a Rabbit Polyclonal antibody detecting IL17RA in WB, ELISA, IF and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for IL17RA antibody (N-Term) (ABIN6991881)

Target: IL17RA (Interleukin 17 Receptor A (IL17RA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL17RA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL17RA Antibody

Binding Specificity: AA 150-200, N-Term

Specificity: IL-17RA antibody is human, mouse and rat reactive. Multiple isoforms of IL-17RA are known to exist. This antibody is predicted to not cross-react with other IL-17 receptor subunits.

Purification: IL-17RA Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-17RA antibody was raised against an 18 amino acid peptide near the amino terminus of human IL-17RA. The immunogen is located within amino acids 150 - 200 of IL-17RA.

Isotype: IgG

Application Details

Application Notes: IL-17RA antibody can be used for detection of IL-17RA by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-17RA Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-17RA antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for IL17RA

Target: IL17RA (Interleukin 17 Receptor A (IL17RA))

Alternative Name: IL-17RA

Background: IL-17RA Antibody: Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1). It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1,2). IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3,4). Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5).

Molecular Weight: Predicted: 95 kDa

Observed: 135 kDa

Gene ID: 23765

NCBI Accession: NP_055154

UniProt: Q96F46

Pathways: SARS-CoV-2 Protein Interactome