DDC antibody (C-Term)

Catalog No. ABIN6991892

The Rabbit Polyclonal anti-DDC antibody is suitable to detect DDC in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IF and IHC (p).

Quick Overview for DDC antibody (C-Term) (ABIN6991892)

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DDC Antibody

Binding Specificity: AA 390-440, C-Term

Specificity: DDC antibody is human, mouse and rat reactive.

Purification: DDC Antibody is affinity chromatography purified via peptide column.

Immunogen: DDC antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DDC. The immunogen is located within amino acids 390 - 440 of DDC .

Isotype: IgG

Application Details

Application Notes: DDC antibody can be used for detection of DDC by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DDC Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DDC antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for DDC

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Alternative Name: DDC

Background: DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1). It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2). It can form a homodimer and is expressed in the central nervous system (2). DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease, neuroendocrine tumors and drug abuse (3,4). Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4).

Molecular Weight: Predicted: 53 kDa

Observed: 53 kDa

Gene ID: 1644

NCBI Accession: NP_000781

UniProt: P20711

Pathways: Dopaminergic Neurogenesis