ERAP1 antibody (C-Term)

Catalog No. ABIN6991899

This anti-ERAP1 antibody is a Rabbit Polyclonal antibody detecting ERAP1 in WB, ELISA, IF and IHC (p). Suitable for Human and Mouse.

Quick Overview for ERAP1 antibody (C-Term) (ABIN6991899)

Target: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ERAP1 Antibody

Binding Specificity: AA 730-780, C-Term

Specificity: ERAP1 antibody is human and mouse reactive. At least two isoforms of ERAP1 are known to exist, this antibody will detect both isoforms. ERAP1 antibody is predicted to not cross-react with ERAP2.

Purification: ERAP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: ERAP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ERAP. The immunogen is located within amino acids 730 - 780 of ERAP1 .

Isotype: IgG

Application Details

Application Notes: ERAP1 antibody can be used for detection of ERAP1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ERAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ERAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ERAP1

Target: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Alternative Name: ERAP1

Background: The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1), a member of the peptidase M1 family, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). It is also designated as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1) (3). ERAP1 is localized to the lumen of the ER and induced by interferon. It may be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (3,4).

Molecular Weight: Predicted: 104 kDa

Observed: 105kDa

Gene ID: 51752

NCBI Accession: NP_057526

UniProt: Q9NZ08