TMEM107 antibody (N-Term)

Catalog No. ABIN6991906

Product Details anti-TMEM107 Antibody

Target: TMEM107 (Transmembrane Protein 107 (TMEM107))

Binding Specificity: AA 20-70, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM107 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (IF)

Specificity: TMEM107 antibody is human specific. At least two isoforms of TMEM107 are known to exist.

Purification: TMEM107 Antibody is affinity chromatography purified via peptide column.

Immunogen: TMEM107 antibody was raised against a 19 amino acid peptide near the amino terminus of human TMEM107. The immunogen is located within amino acids 20 - 70 of TMEM107 .

Isotype: IgG

Application Details

Application Notes: TMEM107 antibody can be used for detection of TMEM107 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TMEM107 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TMEM107antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for TMEM107

Target: TMEM107 (Transmembrane Protein 107 (TMEM107))

Alternative Name: TMEM107 (TMEM107 Products)

Synonyms: zgc:77926 antibody, MGC157051 antibody, GRVS638 antibody, PRO1268 antibody, 1110004B13Rik antibody, 2810049P21Rik antibody, transmembrane protein 107 antibody, Transmembrane protein 107 antibody, transmembrane protein 107 L homeolog antibody, tmem107 antibody, TMEM107 antibody, Tmem107 antibody, Tsp_08866 antibody, tm107 antibody, tmem107.L antibody

Background: Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning (1). It is a 139 amino acid transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1 (1,2). TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types (1,3). TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD) (1-3).

Molecular Weight: Predicted: 16 kDa

Observed: 19kDa

Gene ID: 84314

NCBI Accession: NP_115730

UniProt: Q6UX40