IL1RL2 antibody (AA 260-310)

Catalog No. ABIN6991913

Product Details anti-IL1RL2 Antibody

Target: IL1RL2 (Interleukin 1 Receptor-Like 2 (IL1RL2))

Binding Specificity: AA 260-310

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1RL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: IL-1RL2 antibody is human, mouse and rat reactive. At least three isoforms of IL-1RL2 are known to exist, this antibody will detect all three isoforms. IL-1RL2 antibody is predicted to not cross-react with IL-1R or IL-1RL1.

Purification: IL-1RL2 antibody is affinity chromatography purified via peptide column.

Immunogen: IL-1RL2 antibody was raised against a 16 amino acid peptide near the center of human IL-1RL2. The immunogen is located within amino acids 260 - 310 of IL-1RL2.

Isotype: IgG

Application Details

Application Notes: IL-1RL2 antibody can be used for detection of IL-1RL2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-1RL2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-1RL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for IL1RL2

Target: IL1RL2 (Interleukin 1 Receptor-Like 2 (IL1RL2))

Alternative Name: IL-1RL2 (IL1RL2 Products)

Synonyms: IL-1Rrp2 antibody, IL-36R antibody, IL1R-rp2 antibody, IL1RRP2 antibody, AI481289 antibody, AW551444 antibody, interleukin 1 receptor like 2 antibody, interleukin 1 receptor-like 2 antibody, IL1RL2 antibody, Il1rl2 antibody

Background: IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity (1). Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway (2). IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response (3).

Molecular Weight: Predicted: 61 kDa

Observed: 55 kDa

Gene ID: 8808

NCBI Accession: NP_003845

UniProt: Q9HB29