FIL1d antibody (C-Term)

Catalog No. ABIN6991918

This Rabbit Polyclonal antibody specifically detects FIL1d in WB, ELISA, IHC (p) and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for FIL1d antibody (C-Term) (ABIN6991918)

Target: FIL1d (Interleukin 1 delta (FIL1d))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FIL1d antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-FIL1d Antibody

Binding Specificity: C-Term

Specificity: IL-36RN antibody is human and mouse reactive. At least two isoforms of IL-36RN are known to exist

Purification: IL-36RN antibody is affinity chromatography purified via peptide column.

Immunogen: IL-36RN antibody was raised against a 19 amino acid peptide near the carboxy terminus of human IL-36RN. The immunogen is located within the last 50 amino acids of IL-36RN.

Isotype: IgG

Application Details

Application Notes: IL-36RN antibody can be used for detection of IL-36RN by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-36RN antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-36RN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for FIL1d

Target: FIL1d (Interleukin 1 delta (FIL1d))

Alternative Name: IL-36RN

Background: IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2). The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3). Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4).

Molecular Weight: Observed Molecular Weight: 24 kDa

Gene ID: 26525

NCBI Accession: NP_775262

UniProt: Q9UBH0