TRF2 antibody (N-Term)
Quick Overview for TRF2 antibody (N-Term) (ABIN6991982)
Target
See all TRF2 (TERF2) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- N-Term
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Specificity
- TERF2 antibody is human specific.
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Purification
- TERF2 antibody is affinity chromatography purified via peptide column.
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Immunogen
- TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2. The immunogen is located within the first 50 amino acids of TERF2.
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Isotype
- IgG
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Application Notes
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TERF2 antibody can be used for detection of TERF2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- TERF2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,4 °C
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Storage Comment
- TERF2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))
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Alternative Name
- TERF2
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Background
- The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5).
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Molecular Weight
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Predicted: 60 kDa
Observed: 69 kDa -
Gene ID
- 7014
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NCBI Accession
- NP_005643
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UniProt
- Q15554
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Pathways
- Cell Division Cycle, Telomere Maintenance
Target
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