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TRF2 antibody (N-Term)

The Rabbit Polyclonal anti-TRF2 antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect TRF2 in samples from Human.
Catalog No. ABIN6991982

Quick Overview for TRF2 antibody (N-Term) (ABIN6991982)

Target

See all TRF2 (TERF2) Antibodies
TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Reactivity

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Human

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This TRF2 antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Binding Specificity

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    N-Term

    Specificity

    TERF2 antibody is human specific.

    Purification

    TERF2 antibody is affinity chromatography purified via peptide column.

    Immunogen

    TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2. The immunogen is located within the first 50 amino acids of TERF2.

    Isotype

    IgG
  • Application Notes

    TERF2 antibody can be used for detection of TERF2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    TERF2 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    TERF2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target

    TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

    Alternative Name

    TERF2

    Background

    The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5).

    Molecular Weight

    Predicted: 60 kDa

    Observed: 69 kDa

    Gene ID

    7014

    NCBI Accession

    NP_005643

    UniProt

    Q15554

    Pathways

    Cell Division Cycle, Telomere Maintenance
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