TET2 antibody (C-Term)

Catalog No. ABIN6991984

This Rabbit Polyclonal antibody specifically detects TET2 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for TET2 antibody (C-Term) (ABIN6991984)

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TET2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TET2 Antibody

Binding Specificity: AA 1550-1600, C-Term

Specificity: TET2 antibody is human and mouse reactive. At least two isoforms of TET2 are known to exist, this antibody will detect the larger isoforms. This antibody is predicted to not cross-react with TET1 and TET3.

Purification: TET2 antibody is affinity chromatography purified via peptide column.

Immunogen: TET2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET2. The immunogen is located within amino acids 1550 - 1600 of TET2.

Isotype: IgG

Application Details

Application Notes: TET2 antibody can be used for detection of TET2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TET2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TET2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Alternative Name: TET2

Background: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14 % of patients with JAK2V617F-positive myeloproliferative neoplasms (1), and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia (2). Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.

Molecular Weight: Predicted: 220 kDa

Observed: 220 kDa

Gene ID: 54790

NCBI Accession: NP_001120680

UniProt: Q6N021

Pathways: Warburg Effect